Monday, June 24, 2013

Pakistanis kill 10 tourists, including American

ISLAMABAD (AP) ? At least a dozen Islamic militants wearing police uniforms shot to death overnight a Pakistani and 10 foreign tourists, including an American, who were visiting one of the world's highest mountains in a remote area of northern Pakistan that has been largely peaceful, officials said Sunday.

The shooting was one of the worst attacks on foreigners in Pakistan in recent years and is likely to damage the country's already struggling tourism industry. Pakistan's mountainous north ? considered until now relatively safe ? is one of the main attractions in a country beset with insurgency and other political instability.

The local branch of the Taliban took responsibility for the killings, saying it was to avenge the death of a leader killed in a recent U.S. drone strike.

The 10 foreigners who were killed included two Chinese, one Chinese-American and one Nepalese, said Attaur Rehman, home secretary in the Gilgit-Baltistan area where the attack took place. The other six have not been identified. One Pakistani was also killed, Rehman said.

Matt Boland, the acting spokesman at the U.S. Embassy in Islamabad, confirmed that a U.S. citizen was among the dead, but could not say whether it was a dual Chinese national.

"The U.S. Embassy Islamabad expresses its deepest condolences to the family and friends of the U.S. citizen and the other innocent tourists who were killed in the Northern Areas of Pakistan," Boland said in a statement sent to reporters.

Pakistan's interior minister, Chaudhry Nisar Ali Khan, said earlier that nine foreigners and one Pakistani were killed. He said the dead included five Ukrainians, three Chinese and one Russian. One Chinese tourist was wounded in the attack and was rescued, said Khan.

It's unclear what caused the discrepancy between the two accounts.

The attack took place at the base camp of Nanga Parbat, the ninth highest mountain in the world at 8,126 meters (26,660 feet). Nanga Parbat is notoriously difficult to climb and is known as the "killer mountain" because of numerous mountaineering deaths in the past. It's unclear if the tourists were planning to climb the mountain or were just visiting the base camp, which is located in the Gilgit-Baltistan region of Pakistan.

The gunmen were wearing uniforms used by the Gilgit Scouts, a paramilitary police force that patrols the area, said the interior minister. The attackers abducted two local guides to find their way to the remote base camp. One of the guides was killed in the shooting, and the other has been detained and is being questioned, said Khan.

"The purpose of this attack was to give a message to the world that Pakistan is unsafe for travel," said the interior minister in a speech in the National Assembly, which passed a resolution condemning the incident. "The government will take all measures to ensure the safety of foreign tourists."

Pakistani Taliban spokesman Ahsanullah Ahsan claimed responsibility for the attack, saying their Jundul Hafsa group carried out the shooting as retaliation for the death of the Taliban's deputy leader, Waliur Rehman, in a U.S. drone attack on May 29.

"By killing foreigners, we wanted to give a message to the world to play their role in bringing an end to the drone attacks," Ahsan told The Associated Press by telephone from an undisclosed location.

At least a dozen gunmen were involved in the attack, local police officer Jahangir Khan said.

The attackers beat up the Pakistanis who were accompanying the tourists, took their money and tied them up, said a senior local government official. They checked the identities of the Pakistanis and shot to death one of them, possibly because he was a minority Shiite Muslim, said the official, speaking on condition of anonymity because he was not authorized to talk to reporters.

Although Gilgit-Baltistan is a relatively peaceful area, it has experienced attacks by radical Sunni Muslims on Shiites in recent years.

The attackers took the money and passports from the foreigners and then gunned them down, said the official. It's unclear how the Chinese tourist who was rescued managed to avoid being killed. The base camp has basic wooden huts, but most tourists choose to sleep in their own tents.

Local police chief Barkat Ali said they first learned of the attack when one of the local guides called the police station around 1 a.m. on Sunday. The military airlifted the bodies to Pakistan's capital, Islamabad, Sunday afternoon.

"We hope Pakistani authorities will do their best to find the culprits of this crime," the Ukrainian ambassador to Pakistan, Volodymyr Lakomov, told reporters outside the hospital where the bodies were taken.

The Pakistani government condemned the "brutal act of terrorism" in a statement sent to reporters.

"Those who have committed this heinous crime seem to be attempting to disrupt the growing relations of Pakistan with China and other friendly countries," said a statement issued by the Foreign Ministry.

Pakistan has very close ties with neighboring China and is sensitive to any issue that could harm the relationship. Pakistani officials have reached out to representatives from China and Ukraine to convey their sympathies, the Foreign Ministry said.

Many foreign tourists stay away from Pakistan because of the perceived danger of visiting a country that is home to a large number of Islamic militant groups, such as the Taliban and al-Qaida, which mostly reside in the northwest near the Afghan border. A relatively small number of intrepid foreigners visit Gilgit-Baltistan during the summer to marvel at the peaks of the Himalayan and Karakoram ranges, including K2, the second highest mountain in the world.

Syed Mehdi Shah, the chief minister of Gilgit-Baltistan, condemned the attack and expressed fear that it would seriously damage the region's tourism industry.

"A lot of tourists come to this area in the summer, and our local people work to earn money from these people," said Shah. "This will not only affect our area, but will adversely affect all of Pakistan."

The area has been cordoned off by police and paramilitary soldiers, and a military helicopter was searching the area, said Shah.

"God willing we will find the perpetrators of this tragic incident," said Shah.

The government suspended the chief secretary and top police chief in Gilgit-Baltistan following the attack and ordered an inquiry into the incident, said Khan, the interior minister.

___

Associated Press writer Rasool Dawar contributed to this report from Peshawar, Pakistan.

Source: http://news.yahoo.com/pakistanis-kill-10-tourists-including-american-165447640.html

aubrey huff the killers julianne hough brandy michael pineda charles taylor carl crawford

La Jolla Festival of the Arts Kicks Off at UCSD [Photos] - Entertainment

The La Jolla Festival of the Arts is Saturday and Sunday from 10 a.m. to 5 p.m.

The sun was shining Saturday for the first day of the La Jolla Festival of the Arts at UC San Diego's Warren Field.

The two-day event is produced by Torrey Pines Kiwanis, a non-profit organization that raises funds to support adaptive sports and recreation programs for San Diegans with disabilities.

La Jolla Festival Arts will be from 10 a.m. to 5 p.m. on Saturday, June 22 and Sunday, June 23 at UC San Diego Warren Field.

Tickets are $14 at the door. For more info visit?lajollaartfestival.org.

Become a blogger today!
Get started now

Source: http://lajolla.patch.com/groups/arts-and-entertainment/p/la-jolla-festival-of-the-arts-kicks-off-at-ucsd-photos

john lennon leann rimes pearl harbor Jacintha Saldanha Butch Jones thursday night football japan earthquake

Getting to grips with migraine

Getting to grips with migraine [ Back to EurekAlert! ] Public release date: 23-Jun-2013
[ | E-mail | Share Share ]

Contact: Aileen Sheehy
press.office@sanger.ac.uk
44-012-234-92368
Wellcome Trust Sanger Institute

Researchers identify some of the biological roots of migraine from large-scale genome study

In the largest study of migraines, researchers have found 5 genetic regions that for the first time have been linked to the onset of migraine. This study opens new doors to understanding the cause and biological triggers that underlie migraine attacks.

The team identified 12 genetic regions associated with migraine susceptibility. Eight of these regions were found in or near genes known to play a role in controlling brain circuitries and two of the regions were associated with genes that are responsible for maintaining healthy brain tissue. The regulation of these pathways may be important to the genetic susceptibility of migraines.

Migraine is a debilitating disorder that affects approximately 14% of adults. Migraine has recently been recognized as the seventh disabler in the Global Burden of Disease Survey 2010 and has been estimated to be the most costly neurological disorder. It is an extremely difficult disorder to study because no biomarkers between or during attacks have been identified so far.

"This study has greatly advanced our biological insight about the cause of migraine," says Dr Aarno Palotie, from the Wellcome Trust Sanger Institute. "Migraine and epilepsy are particularly difficult neural conditions to study; between episodes the patient is basically healthy so it's extremely difficult to uncover biochemical clues.

"We have proven that this is the most effective approach to study this type of neurological disorder and understand the biology that lies at the heart of it."

The team uncovered the underlying susceptibilities by comparing the results from 29 different genomic studies, including over 100,000 samples from both migraine patients and control samples.

They found that some of the regions of susceptibility lay close to a network of genes that are sensitive to oxidative stress, a biochemical process that results in the dysfunction of cells.

The team expects many of the genes at genetic regions associated with migraine are interconnected and could potentially be disrupting the internal regulation of tissue and cells in the brain, resulting in some of the symptoms of migraine.

"We would not have made discoveries by studying smaller groups of individuals," says Dr Gisela Terwindt, co-author from Leiden University Medical Centre. "This large scale method of studying over 100,000 samples of healthy and affected people means we can tease out the genes that are important suspects and follow them up in the lab."

The team identified an additional 134 genetic regions that are possibly associated to migraine susceptibility with weaker statistical evidence. Whether these regions underlie migraine susceptibility or not still needs to be elucidated. Other similar studies show that these statistically weaker culprits can play an equal part in the underlying biology of a disease or disorder.

"The molecular mechanisms of migraine are poorly understood. The sequence variants uncovered through this meta-analysis could become a foothold for further studies to better understanding the pathophysiology of migraine" says Dr Kri Stefnsson, President of deCODE genetics.

"This approach is the most efficient way of revealing the underlying biology of these neural disorders," says Dr Mark Daly, from the Massachusetts General Hospital and the Broad Institute of MIT and Harvard. "Effective studies that give us biological or biochemical results and insights are essential if we are to fully get to grips with this debilitating condition.

"Pursuing these studies in even larger samples and with denser maps of biological markers will increase our power to determine the roots and triggers of this disabling disorder."

###

Notes to Editors

Publication Details

Verneri Anttila, Bendik S. Winsvold, Padhraig Gormley et al (2013) 'Genome-wide meta-analysis identifies new susceptibility loci for migraine' Advanced online publication in Nature Genetics 23 June Doi: 10.1038/ng.2676

Participating centres

A full list of participating centres can be found in the study

Funding

A full list of funding can be found in the study

Selected Websites

The Eli and Edythe L. Broad Institute of Harvard and MIT was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods and data openly to the entire scientific community.

Founded by MIT, Harvard and its affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. For further information about the Broad Institute, go to http://www.broadinstitute.org.

The Wellcome Trust Sanger Institute is one of the world's leading genome centres. Through its ability to conduct research at scale, it is able to engage in bold and long-term exploratory projects that are designed to influence and empower medical science globally. Institute research findings, generated through its own research programmes and through its leading role in international consortia, are being used to develop new diagnostics and treatments for human disease. http://www.sanger.ac.uk

The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. We support the brightest minds in biomedical research and the medical humanities. Our breadth of support includes public engagement, education and the application of research to improve health. We are independent of both political and commercial interests. http://www.wellcome.ac.uk


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Getting to grips with migraine [ Back to EurekAlert! ] Public release date: 23-Jun-2013
[ | E-mail | Share Share ]

Contact: Aileen Sheehy
press.office@sanger.ac.uk
44-012-234-92368
Wellcome Trust Sanger Institute

Researchers identify some of the biological roots of migraine from large-scale genome study

In the largest study of migraines, researchers have found 5 genetic regions that for the first time have been linked to the onset of migraine. This study opens new doors to understanding the cause and biological triggers that underlie migraine attacks.

The team identified 12 genetic regions associated with migraine susceptibility. Eight of these regions were found in or near genes known to play a role in controlling brain circuitries and two of the regions were associated with genes that are responsible for maintaining healthy brain tissue. The regulation of these pathways may be important to the genetic susceptibility of migraines.

Migraine is a debilitating disorder that affects approximately 14% of adults. Migraine has recently been recognized as the seventh disabler in the Global Burden of Disease Survey 2010 and has been estimated to be the most costly neurological disorder. It is an extremely difficult disorder to study because no biomarkers between or during attacks have been identified so far.

"This study has greatly advanced our biological insight about the cause of migraine," says Dr Aarno Palotie, from the Wellcome Trust Sanger Institute. "Migraine and epilepsy are particularly difficult neural conditions to study; between episodes the patient is basically healthy so it's extremely difficult to uncover biochemical clues.

"We have proven that this is the most effective approach to study this type of neurological disorder and understand the biology that lies at the heart of it."

The team uncovered the underlying susceptibilities by comparing the results from 29 different genomic studies, including over 100,000 samples from both migraine patients and control samples.

They found that some of the regions of susceptibility lay close to a network of genes that are sensitive to oxidative stress, a biochemical process that results in the dysfunction of cells.

The team expects many of the genes at genetic regions associated with migraine are interconnected and could potentially be disrupting the internal regulation of tissue and cells in the brain, resulting in some of the symptoms of migraine.

"We would not have made discoveries by studying smaller groups of individuals," says Dr Gisela Terwindt, co-author from Leiden University Medical Centre. "This large scale method of studying over 100,000 samples of healthy and affected people means we can tease out the genes that are important suspects and follow them up in the lab."

The team identified an additional 134 genetic regions that are possibly associated to migraine susceptibility with weaker statistical evidence. Whether these regions underlie migraine susceptibility or not still needs to be elucidated. Other similar studies show that these statistically weaker culprits can play an equal part in the underlying biology of a disease or disorder.

"The molecular mechanisms of migraine are poorly understood. The sequence variants uncovered through this meta-analysis could become a foothold for further studies to better understanding the pathophysiology of migraine" says Dr Kri Stefnsson, President of deCODE genetics.

"This approach is the most efficient way of revealing the underlying biology of these neural disorders," says Dr Mark Daly, from the Massachusetts General Hospital and the Broad Institute of MIT and Harvard. "Effective studies that give us biological or biochemical results and insights are essential if we are to fully get to grips with this debilitating condition.

"Pursuing these studies in even larger samples and with denser maps of biological markers will increase our power to determine the roots and triggers of this disabling disorder."

###

Notes to Editors

Publication Details

Verneri Anttila, Bendik S. Winsvold, Padhraig Gormley et al (2013) 'Genome-wide meta-analysis identifies new susceptibility loci for migraine' Advanced online publication in Nature Genetics 23 June Doi: 10.1038/ng.2676

Participating centres

A full list of participating centres can be found in the study

Funding

A full list of funding can be found in the study

Selected Websites

The Eli and Edythe L. Broad Institute of Harvard and MIT was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods and data openly to the entire scientific community.

Founded by MIT, Harvard and its affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. For further information about the Broad Institute, go to http://www.broadinstitute.org.

The Wellcome Trust Sanger Institute is one of the world's leading genome centres. Through its ability to conduct research at scale, it is able to engage in bold and long-term exploratory projects that are designed to influence and empower medical science globally. Institute research findings, generated through its own research programmes and through its leading role in international consortia, are being used to develop new diagnostics and treatments for human disease. http://www.sanger.ac.uk

The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. We support the brightest minds in biomedical research and the medical humanities. Our breadth of support includes public engagement, education and the application of research to improve health. We are independent of both political and commercial interests. http://www.wellcome.ac.uk


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-06/wtsi-gtg062113.php

Miley Cyrus Twerking Jesus Shuttlesworth Michael Hastings mac miller bruno mars Hunter Hayes Born Sinner

Trial provides portrait of Jackson as a father

LOS ANGELES (AP) ? Courtrooms have supplied the epilogue to Michael Jackson's life. They've provided the forum where his debts have been settled, his final days dissected and his life depicted as a cautionary tale.

In nearly four years of court proceedings, two juries have watched Jackson come to life on video screens. They've watched him spin, dance, and then disappear. They've heard his voice, seen his handwriting and viewed photos of his lifeless body.

His role as a father has been described in little more than platitudes. Until now.

The jury hearing a civil case filed by the superstar's mother ? against AEG Live LLC, the promoter of Jackson's ill-fated concerts ? are experiencing details of a world previously held under lock and key. They've heard of extravagant birthday parties, secret family outings and the leg-clinging devotion of his children.

Jackson shielded the youngsters from the public eye, home-schooling them and often hiding their faces in public.

Away from the cameras, Jackson tried to create an environment of love, attention and special moments for his children, Michael Joseph "Prince" Jackson Jr., Paris-Michael Katherine Jackson and Prince Michael "Blanket" Jackson.

The following are some of some of the stories they've told. They present a portrait of Jackson as a father that outsiders never saw.

___

The final month of Jackson's life was a busy time. There were rehearsals for "This Is It," planning meetings and film shoots for a series of mini-movies that would precede some of his greatest hits at the London shows.

Jackson brought his children to the shoot for a "Smooth Criminal" video that culminated with Jackson leaping through a window while being shot at by Humphrey Bogart.

Alif Sankey, a backup dancer on the original video who was working on the comeback concerts, sat next to Paris during the shoot. The 11-year-old wanted to share a secret and opened up her purse.

It was filled with candy, Sankey recalled.

Jackson didn't want his children to eat sweets, and Paris asked Sankey to keep it quiet.

The dancer noticed something else inside the purse ? tiny picture frames with images of her father.

"Her purse was full of candy and pictures of Daddy."

___

Despite being home-schooled, there was no shortage of companions for Jackson's children.

Chef Kai Chase recalled numerous pets in the mansion that Jackson was renting while he prepared for his "This Is It" shows.

There was the talking bird, Siberia, who whistled at pretty women.

The children also had a chocolate Labrador named Kenya, whom Chase bought a cookbook for so she could bake him treats and a birthday cake. Two cats, named Katie and Thriller, also roamed the house.

During opening statements of the civil trial, some of the jury's first exposure to life in the Jackson home came from footage shot on a Christmas morning several years ago. Jackson's ode to his children, "You Are My Life" played as jurors watched a video of a Christmas morning from years ago of Prince, Paris and Blanket gleefully receiving their gifts, which included the puppy, Kenya.

___

Chase had been working at Jackson's home for only a few days when it came time to prepare for Paris' 11th birthday.

She wanted a Michael Jackson-themed party.

All around the dining room, posters of the King of Pop were hung alongside album covers and other pictures. Jackson's hit songs played as the family ate cheese pizza, hot wings and banana splits, Chase recalled.

Paris' birthday cake was decorated with Lilo & Stitch, her favorite Disney characters. But the festivities weren't over.

Jackson escorted the children into the backyard, where they watched a private Cirque du Soleil-style circus, complete with men on stilts and a woman performing in a giant balloon.

Chase watched from the kitchen window and later described the scene as "the most beautiful expression of love I've ever seen."

___

Jackson spent the final months of his life in a rented mansion in the upscale Holmby Hills section of Los Angeles.

The mansion had all the amenities fit for a pop superstar ? a palatial entryway, staircase and parlor and in the basement, a home theater and dance studio.

The house was a hub of activity, with security guards posted outside, a pair of housekeepers, a nanny for the children and on many days, a personal chef stationed in the kitchen.

Dinners at the home occasionally featured special guests, including Jackson's personal physician Conrad Murray and choreographer Travis Payne.

But staffers and guests other than Murray weren't allowed upstairs, where the bedrooms were. When Chase wanted to prepare a soul food menu for Jackson and his children, she wrote him a note in Magic Marker and left it at the foot of the stairs.

AEG Live's lead defense attorney has pointed to the secrecy of Jackson's upstairs lifestyle ? where the superstar was receiving nightly doses of the anesthetic propofol in his locked bedroom ? to support the company's contention it couldn't have known about Jackson's drug treatments.

___

Having a stable home for his children was a major motivation for Jackson returning to the concert stage, AEG executives say.

After his acquittal of child molestation charges in 2005, Jackson had become a nomad, spending time in various cities, including Las Vegas, often staying with friends.

"He wanted his kids to have a permanent place to live and a sense of community," AEG Live CEO Randy Phillips recalled Jackson telling him during one meeting held while the family was living in the guesthouse of a rich benefactor.

It was Halloween and the children darted in and out of the rooms, wearing masks. Later that night, they'd go with their father to a party at Elizabeth Taylor's home.

"I felt incredibly bad that this incredible star was at this point where he couldn't buy a house," Phillips said.

___

Jackson was always a magnet for photographers and fans, but he managed to sneak his children into a movie just weeks before his death.

The family and a few others went to see the animated film "Up" at the El Capitan Theatre on a touristy stretch of Hollywood Boulevard.

They came in a back door and remained in a private room while moviegoers filed into the theater. When everyone else was seated, the entourage, including his longtime makeup artist Karen Faye, director Kenny Ortega and others, hit up the concession stand.

The group watched the movie without distraction. "No one knew Michael was there," Faye recalled.

___

Jackson and choreographer Travis Payne were scheduled to rehearse one-on-one several days a week in the dance studio that was in the basement of Jackson's mansion.

It's unclear how often the pair worked out, but when they did they often had a companion, 7-year-old Blanket. He liked to watch his father dance, Payne later recalled, and tried to always stay close to his dad. During their workouts, Payne said Jackson talked to his son, mentoring him.

Preparations for the shows meant that Jackson was frequently out of the house at meetings, film shoots or rehearsals. When he returned home, Prince, Paris and Blanket would rush their father.

"They would take off like lightning," Chase recalls, "... and grab him around the ankles and around the waist."

They'd be hanging off of him, not unlike a picture shown to jurors during opening statements.

In the photo, Jackson was handing Blanket, then a newborn, to President Bill Clinton. Clinging to Jackson's right leg was Paris.

___

When it came time for a science project, Paris settled on studying snails.

She enlisted Chase to help her find snails in the mansion's backyard. The pair carried large flashlights and found several of the slimy creatures and prepared to bring them inside.

Jackson was waiting for them.

"At this point, I knew I was going to get fired," Chase recalled.

The singer looked at the snails and had a different reaction ? he helped make them a home.

The snails ended up in jars made cozier by moss in the bottom and tiny cocktail umbrellas. They lived on the kitchen counter, not far from other reminders of the children.

Blanket's colorings hung on the refrigerator.

On a chalkboard where Chase would write out menus, Paris scrawled a message that remained on the board the day her father died.

"I love daddy," the 11-year-old wrote. "Smile, it's free."

___

Anthony McCartney can be reached at http://twitter.com/mccartneyAP

Source: http://news.yahoo.com/trial-provides-portrait-jackson-father-154431713.html

Mario Machado May the Fourth be with you James Righton finish line kentucky derby Iron Man 3 Emmett Till